A Front Royal woman traveling in the wrong direction on Interstates 66 and 81 died in a head-on collision Thursday.

Patricia Murray, 66, of Front Royal, was pronounced dead upon arrival at the Winchester Medical Center following the two-vehicle crash on I-81, according to state police news release.

State police were alerted at 3:19 p.m. Thursday about a 2007 Toyota Yaris traveling in the wrong direction in the eastbound lanes of Interstate 66 near mile marker three.

Corrine Geller, state police public relations director, stated in an email Friday that investigators are still attempting to determine how and when Murray entered I-66 in the wrong direction.

As Trooper T.V. Clark was responding, the release states that “the Toyota made its way onto Interstate 81 heading south in the northbound lanes.”

Murray’s vehicle collided head-on at 3:25 p.m. with a 1996 Honda that was traveling north in the northbound lanes at the 299-mile marker on I-81 near the Shenandoah-Frederick county line.

Chris A. Nesselrodt, 22, of Broadway, was driving the Honda and was transported to Inova Fairfax Hospital with serious injuries, the release states.

There were four passengers in the Honda, including a 19-year-old female and two 17-year-old males who were transported to Winchester Medical Center with non-life threatening injuries, and a 20-year-old male who was not injured.

Geller stated in the email that alcohol was not a factor and the crash remains under investigation.

Strasburg Police Chief Wayne Sager said over the phone Friday that closures on Interstate 81 diverted traffic through Strasburg and the roads were backed up for a couple of hours following the crash.

– Contact Josh Gully at jgully@nvdaily.com